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Wolfgang Baumeister's research group uses cryo-electron tomography to study the molecular structure of frozen hydrated cells. Applications include tripeptidyl peptidase II, 70S ribosome, cell walls and membranes, and synaptic complexes. The group has spent over 20 years pioneering the development of cryo-electron tomography for visualizing macromolecular complexes in their functional cellular context. The website includes summaries of recent research and s link to download the TOM toolbox for electron tomography acquisition and analysis.
The laboraotry uses structural biology techniques including electron cryo-microscopy (cryo EM) to study the structures of membrane proteins. The group developed the techniques of fragment based phase extension and MicroED.
The lab in involved in research at the nano-scale level on the macromolecular organization of cells under normal and pathogenic conditions. The group is developing cryo-electron microscopy techniques for 3-d imaging that will show where proteins are located in cells and how proteins work together in complex structures. Live cell imaging with a fully integrated spinning disk, foccussed ion beam thininning, and cryo-electron tomography are used to obtain molecular resolution of molecular machines in cells in a near-native situation.
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